特聘研究員 / 本院生醫所
EDUCATION AND POSITIONS HELD:
- Ph.D. (Chemical Physics), University of Minnesota (1984)
- Postdoctoral Fellow, AT&T Bell Laboratories @ Murray Hill (1984-1986)
- Research Associate, Harvard University (1986-1990)
- Assistant Professor of Molecular & Medical Genetics, Biochemistry and Chemistry, University of Toronto (1990-1994)
- Associate to Full Research Fellow, Institute of Biomedical Sciences, Academia Sinica (1995-present)
- Associate to Full Professor of Chemistry, National Tsing Hua University (1995-present)
- National Science Council “Outstanding Scientist” Award, 2000-2002
- Foundation for the Advancement of Outstanding Scholarship “Outstanding Scholar” Award, 2003-2008
Research in the lab encompasses the following three areas:
1. Protein Binding and Folding: we are performing systematic studies to unravel the fundamental principles governing protein-metal, protein-protein and protein-nucleic acid binding affinity and specificity as well as metal-induced folding of metalloproteins.
2. Structure-based Rational Drug Design: our focus is on the structure-based rational design of anti-cancer and anti-viral agents as well as antibiotics.
3. New Algorithms and Theories: we are developing new algorithms to identify key protein targets involved in diseases as well as implicit solvent models for computer simulations.
A variety of methods are employed including ab initio quantum mechanics methods, molecular dynamics simulations, continuum dielectric methods, solvation theory, protein docking, homology modeling, and database mining. Our research is at the interface of biology, physics, chemistry, and computer science.
A candidate linker (in yellow) with the potential of restoring the DNA (in orange)-binding activity of mutant R273H p53 (in green)